Distribution of ITPA P32T alleles in multiple world populations

Functional study of the P32T ITPA variant associated with drug sensitivity in humans.

Sanitization of the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into ...

The human ITPA polymorphic variant P32T is destabilized by the unpacking of the hydrophobic core.

Inosine triphosphate pyrophosphatase (ITPA), a key enzyme involved in maintaining the purity of cellular nucleoside triphosphate pools, specifically recognizes inosine triphosphate and xanthosine triphosphate (including the deoxyribose forms) and detoxifies them by catalyzing the hydrolysis of a phosphoanhydride bond, releasing pyrophosphate. This prevents their inappropriate use as substrates ...

Frequency of Apolipoprotein E Alleles in Iranian Populations

The Distribution of Self-Sterility Alleles in Populations.

H E phenomenon of self-sterility is known to be very common among T higher plants. The genetic mechanism in most cases studied seems to be that discovered by EAST and MANGELSDORF in Nicotiana data and N . Sanderae. A single series of alleles, S1, Sz . . . , is involved. The growth of a pollen tube is so much inhibited in a style whose cells contain the same allele that it does not reach the emb...

the tragedy of modern man in arthur millers world

what miller wants is a theatre of heightened consciousness. he speaks of two passions in a man, the passion to "feel" and the passion "know". he belives that we can have more of the latter. he says: drama is akin to the other inventions of man in that it ought to help us know more and not merely to spend our feelings. the writing of the crucible shows us that he is trying to give more heightene...